Researchers have restored vision in old mice and in mice with damaged retinal nerves by resetting some of the thousands of chemical marks that accumulate on DNA as cells age. The work, published on 2 December in Nature¹, suggests a new approach to reversing age-related decline, by reprogramming some cells to a ‘younger’ state in which they are better able to repair or replace damaged tissue.

“It is a major landmark,” says Juan Carlos Izpisua Belmonte, a developmental biologist at the Salk Institute for Biological Studies in La Jolla, California, who was not involved in the study. “These results clearly show that tissue regeneration in mammals can be enhanced.”

But researchers also caution that the work has so far has been carried out only in mice, and it remains to be seen whether the approach will translate to people, or to other tissues and organs that are ravaged by time.

Visionary approach

Ageing affects the body in myriad ways — among them, adding, removing or altering chemical groups such as methyls on DNA. These ‘epigenetic’ changes accumulate as a person ages, and some researchers have proposed tracking the changes as a way of calibrating a molecular clock to measure biological age, an assessment that takes into

account biological wear-and-tear and can differ from chronological age.

That has raised the possibility that epigenetic changes contribute to the effects of ageing. “We set out with a question: if epigenetic changes are a driver of ageing, can you reset the epigenome?” says David Sinclair, a geneticist at Harvard Medical School in Boston, Massachusetts, and a co-author of the Nature study. “Can you reverse the clock?

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Experts highlight advances with the potential to revolutionize industry, health care and society

If some of the many thousands of human volunteers needed to test coronavirus vaccines could have been replaced by digital replicas—one of this year’s Top 10 Emerging Technologies—COVID-19 vaccines might have been developed even faster, saving untold lives. Soon virtual clinical trials could be a reality for testing new vaccines and therapies. Other technologies on the list could reduce greenhouse gas emissions by electrifying air travel and enabling sunlight to directly power the production of industrial chemicals. With “spatial” computing, the digital and physical worlds will be integrated in ways that go beyond the feats of virtual reality. And ultrasensitive sensors that exploit quantum processes will set the stage for such applications as wearable brain scanners and vehicles that can see around corners.

These and the other emerging technologies have been singled out by an international steering group of experts. The group, convened by Scientific American and the World Economic Forum, sifted through more than 75 nominations. To win the nod, the technologies must have the potential to spur progress in societies and economies by outperforming established ways of doing things. They also need to be novel (that is, not currently in wide use) yet likely to have a major impact within the next three to five years. The steering group met (virtually) to whittle down the candidates and then closely evaluate the front-runners before making the final decisions. We hope you are as inspired by the reports that follow as we are.

1. MICRONEEDLES COULD ENABLE PAINLESS INJECTIONS AND BLOOD DRAWS

2. SUN-POWERED CHEMISTRY CAN TURN CARBON DIOXIDE INTO COMMON MATERIALS

3. VIRTUAL PATIENTS COULD REVOLUTIONIZE MEDICINE

4. SPATIAL COMPUTING COULD BE THE NEXT BIG THING

5. DIGITAL MEDICINE CAN DIAGNOSE AND TREAT WHAT AILS YOU

6. ELECTRIC AVIATION COULD BE CLOSER THAN YOU THINK

7. LOW-CARBON CEMENT CAN HELP COMBAT CLIMATE CHANGE

8. QUANTUM SENSORS COULD LET AUTONOMOUS CARS ‘SEE’ AROUND CORNERS

9. GREEN HYDROGEN COULD FILL BIG GAPS IN RENEWABLE ENERGY

10. WHOLE-GENOME SYNTHESIS WILL TRANSFORM CELL ENGINEERING

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How an obscure Turkish scientist’s obscure theoretical breakthrough helped the Chinese tech giant gain control of the future. US telecoms never had a chance.

(A worth reading article on 5G network war between USA and China. Turkish Scientist, Erdal Arikan, discovered “Polar codes” (backbone of 5G network) to transmit high volume data at high speed and without noise error. He offered to US companies, but they refused, but Chinese company, Huawei, jumped on it. It made Huawei a force to reckon with in 5G network. This is the major friction between USA and China, other trade war is just a noise. f.sheikh)

“Polar codes itself is not what’s important,” Erdal continued. “It is a symbol. 5G is totally different than the internet. It’s like a global nervous system. Huawei is the leading company in 5G. They will be around in 10, 20, 50 years—you cannot say that about the US tech companies. In the internet era, the US produced a few trillion-dollar companies. Because of 5G, China will have 10 or more trillion-dollar companies. Huawei and China now have the lead.”

US companies and the US government can no longer expect to beat China back with threats or indictments, even if they are sometimes warranted. And it’s not just telecom companies like Huawei. For all the furor at the highest levels over whether the teen-oriented social app TikTok presented security issues, the real threat to American business was that its Chinese engineers had devised an AI-powered recommendation engine that Silicon Valley had not matched.

Arıkan says the experience has led him to respect Huawei—and to provide a warning to the country where he learned information theory. “I owe a lot to the US,” he says. “I give you friendly advice: You have to accept this as the new reality and deal with it accordingly.”

To paraphrase Shannon: No one knows the future. But Huawei and China now have a hand in controlling it.

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posted by f.sheikh